© This article copyright 2010 by AuntMinnie.com. Any copying, republication or redistribution of AuntMinnie.com content is expressly prohibited without the prior written consent ofAuntMinnie.com.
Structural, functional and molecular imaging of patients with brain tumours is feasible with diagnostic imaging quality using simultaneous hybrid PET/MR image acquisition, according to a study in the August issue of the Journal of Nuclear Medicine.
A pilot study in Germany of 10 patients with intracranial masses found no significant artefacts or distortions using a hybrid scanner configuration that features an MRI-compatible PET insert placed in the magnet bore. The lead author of the study was Andreas Boss, from the department of diagnostic and interventional radiology at Eberhard Karls University Tübingen in Germany (JNM 51 1198).
As the authors noted, previous studies have indicated that only half of low-grade gliomas can be correctly classified using conventional contrast-enhanced MRI. In addition, conventional MRI may be insensitive to post-therapy changes. With PET's ability to provide biochemical and metabolic information, researchers surmised that the two modalities together "may increase diagnostic accuracy over the single modalities."
Between August 2008 and November 2009, 10 patients with a median age of 51 years (range, 34 to 73 years) participated in the pilot study. All patients initially received a brain PET/CT scan, followed immediately by PET/MRI.
Patient diagnoses
At the time of the patient referrals, diagnoses included three cases of meningioma, two patients with low-grade astrocytoma, two cases of glioblastoma, and one case each of suspected low-grade astrocytoma, anaplastic astrocytoma, and atypical neurocytoma.
For the glial tumours, the radiotracer carbon-11 (C-11) methionine was used for PET imaging. In the cases of meningiomas, gallium-68 DOTA-tyr3-octreotide (Ga-68 DOTATOC) was administered.
Data acquisition from the PET scanner (Hi-Rez Biograph 16, Siemens Healthcare, Erlangen, Germany) started at 30 minutes after the injection of methionine and lasted for eight minutes. When DOTATOC was used, acquisition started at 20 minutes after injection and lasted for four minutes. A noncontrast-enhanced low-dose CT scan was used for attenuation correction in the glioma patients, while a contrast-enhanced CT scan was used for meningioma patients.
PET/MRI exams
All PET/MRI scans were performed with a hybrid PET/MRI system capable of simultaneous PET/MR imaging of the brain and skull base. The system consisted of an MRI-compatible PET scanner (BrainPET, Siemens), which was inserted into a modified 3-tesla whole-body MRI scanner (Magnetom Trio Tim, Siemens).
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| PET/MR images |
The researchers acquired PET and MRI data simultaneously, starting 30 to 60 minutes after PET/CT acquisition. The PET scan was conducted for 30 minutes, producing approximately 5 GB of raw data. The PET datasets then were reconstructed by 3D algorithm. Attenuation maps were computed from 3D MRI datasets using an algorithm combining pattern recognition and atlas registration.
Upon review of the resulting images, the researchers determined that the MRI datasets acquired during simultaneous PET acquisition "showed diagnostic image quality, without apparent artefacts or distortions."
The one exception was when a 4 mm Gaussian filter was not used and the PET datasets from concurrent PET/MRI scans "exhibited slight streak artefacts, which were best visible in the sagittal and coronal reformations," the researchers noted. "After filtering, these artefacts were hardly visible."
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| PET/CT vs PET/MRI |
The group also found that radiotracer decay between the PET/CT and PET/MRI acquisitions was effectively compensated by the longer scanning duration and better scanner sensitivity.
"Our study indicates that hybrid PET/MRI of intracranial tumours using C-11 methionine or Ga-68 DOTATOC can be reliably performed," Boss and his colleagues wrote. "The image quality and quantitative data achieved using PET/MRI is similar to that using PET/CT."
In addition, the authors noted that the combination of PET with MRI, instead of CT, "offers many advantages, such as higher soft-tissue contrast; reduced radiation exposure; and advanced MRI techniques such as perfusion imaging, diffusion imaging, and MR spectroscopy."
Additional clinical benefits are that PET with MRI can reduce a patient's exposure to ionizing radiation, which is present with CT.
© This article copyright 2010 by AuntMinnie.com. Any copying, republication or redistribution of AuntMinnie.com content is expressly prohibited without the prior written consent ofAuntMinnie.com.
About the author
Wayne Forrest is an AuntMinnie.com staff writer.
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